5-(3-Bromo-4-fluorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazine → 5-[4-Fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine

Participants

Reaction Steps

5-(3-Bromo-4-fluorophenyl)-3-(4-methoxyphenyl)-[1,2,4]triazine (100 mg, 0.28 mmol) was coupled to 3-fluoro-2-tributylstannylpyridine (129 mg, 0.33 mmol) using the method described in Example 22 to give 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine as a pale yellow solid (40 mg): δH (400 MHz, CDCl3) 3.91 (3H, s), 7.04-7.08 (2H, m), 7.39-7.47 (2H, m), 7.56-7.61 (1H, m), 8.41-8.45 (1H, m), 8.54 (1H, dd, J 2.3, 6.7 Hz), 8.60-8.64 (3H, m), 9.57 (1H, s); m/z (ES+) 377.

Provenance & Evidence