2-(4-Chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane → 3-(4-Chloro-2-fluorophenyl)-5-[4-fluoro-3-(3-fluoro-pyridin-2-yl)phenyl]-[1,2,4]triazine

Participants

Reaction Steps

A solution of 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine and 2-(4-chloro-2-fluorophenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane were coupled together by the method of Example 2 to give 3-(4-chloro-2-fluorophenyl)-5-[4-fluoro-3-(3-fluoro-pyridin-2-yl)phenyl]-[1,2,4]triazine: δH (500 MHz, CDCl3) 7.30-7.35 (2H, m), 7.40-7.46 (2H, m), 7.53-7.61 (1H, m), 8.26 (1H, t, J8.2 Hz), 8.42-8.45 (1H, m), 8.54 (1H, dd, J 2.4, 6.6 Hz), 8.62 (1H, d, J 4.6 Hz), 9.69 (1H, s); m/z (ES+) 399.

Provenance & Evidence