5-[4-Fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine → 3-(3,5-Difluoro-pyridin-2-yl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine

Participants

Reaction Steps

A solution of 5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine and 3, 5-difluoro-2-tributylstannylpyridine were coupled together by the method of Example 36 to give 3-(3,5-difluoro-pyridin-2-yl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine: δH (500 MHz, CDCl3) 7.34 (1H, m), 7.40-7.48 (2H, m), 7.56-7.60 (1H, m), 8.43-8.46 (1H, m), 8.54 (1H, dd, J 2.4, 6.6 Hz), 8.61 (2H, m), 9.78 (1H, s); m/z (ES+) 384.

Provenance & Evidence