HuagongsheHuagongshe Chemistry Print Report · For research reference only
Carbonic acid, compound with phenylguanidine (1:1) → 2-Anilino-4-(1,2-dimethylimidazol-5-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Carbonic acid, compound with phenylguanidine (1:1) | HCID 16217093 | — |
| Reactant | 2-(3-Chloroanilino)-4-(2-methylimidazol-5-yl)pyrimidin | HCID 22273485 | — |
| Product | 2-Anilino-4-(1,2-dimethylimidazol-5-yl)pyrimidine | HCID 22273480 | 26.3% |
Reaction Steps
5-(3-Dimethylaminoprop-2-enoyl)-1,2-dimethylimidazole (Method 1; 314 mg, 1.62 mmol) and phenylguanidine hydrogen carbonate (321 mg, 1.62 mmol) were treated as described in Example 1 to give the title compound 113 mg, (26%) as a solid. NMR: 2.37 (s, 3H), 3.93 (s, 3H), 6.95 (t, 1H), 7.08 (d, 1H), 7.28 (t, 2H), 7.59 (s, 1H), 7.69 (d, 2H), 8.35 (d, 1H), 9.43 (s, 1H); m/z: 266.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969714B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-5c817a6ae793400f94537907eaa785a1 |
| Source note | uspto-grants-2005_11 |