HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1064322Generated: October 31, 2026
Dimethylformamide dimethyl acetal → 5-(3-Dimethylaminoprop-2-en-1-oyl)-1,2-dimethylimidazole
https://huagongshe.com/reaction/1064322
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | 3-(dimethylamino)-1-(2-methyl-1H-imidazol-5-yl)-2-propen-1-one | HCID 1477092 | — |
| Product | 5-(3-Dimethylaminoprop-2-en-1-oyl)-1,2-dimethylimidazole | HCID 69310549 | 29% |
Reaction Steps
5-(3-Dimethylaminoprop-2-enoyl)-2-methylimidazole (350 mg, 1.95 mmol) was suspended in DMFDMA (14 ml) and the mixture stirred and heated at 100° C. for 56 hours. The excess DMFDMA was removed by evaporation and the residue purified by chromatography eluting with DCM/MeOH (94:6) to give the title compound 111 mg, (29%) as a solid. NMR (CDCl3): 2.40 (s, 3H), 3.00 (s, 6H), 3.88 (s, 3H), 5.50 (d, 1H), 7.47 (s, 1H), 7.65 (d, 1H); m/z 194.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06969714B2 |
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| Source dataset | uspto-grants-2005_11 |
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| ORD ID | ord-3889cb8d7a894cf39623f3520a3c7a05 |
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| Source note | uspto-grants-2005_11 |
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