反应详情

温度

0 °C

To the solution of 5 g of 2-amino-3-cyano-4-benzylaminoquinoline in 30 ml of pyridine 6 ml of 3-methylbenzoyl chloride are dropped, under stirring at 0° C. The reaction mixture is stirred at 80° C. for 8 hour, then it is poured onto 150 ml of ice-water. The precipitate is filtered off, washed twice with 40 ml of water. The resulting white crystalline material is recrystallized from 200 ml of ethanol to give 9.2 g of the title compound, mp.: 234° C.

1. stirringThe reaction mixture is stirred at 80° C. for 8 hour
2. filtrationThe precipitate is filtered off
3. washwashed twice with 40 ml of water
4. customThe resulting white crystalline material is recrystallized from 200 ml of ethanol