HCID 22272885, compound → HCID 17858447, compound

HRID 1064358Notes

Reaction equation

HRID 1064358 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:23]([F:24])=[CH:22][C:17]3[NH:18][C:19](=[S:21])[NH:20][C:16]=3[CH:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(OC(N1CCN([C:38]2[C:47]([Cl:48])=[CH:46]C3NC(=S)N[C:40]=3[CH:39]=2)CC1)=O)(C)(C)C>>[ClH:48].[ClH:48].[CH2:39]([CH:38]([S:21][C:19]1[NH:18][C:17]2[CH:22]=[C:23]([F:24])[C:14]([N:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[CH:15][C:16]=2[N:20]=1)[CH2:47][CH3:46])[CH3:40]

Participants

3

Reactant 2

HCID 22272885HCID 22272885, compoundHCID 22272977HCID 22272977, compound

Product 1

HCID 17858447HCID 17858447, compound

Procedure

Reactions were conducted following Example 1 except that 5-(4-tert-butoxycarbonylpiperazin-1-yl)-6-fluoro-1,3-dihydro-2H-benzimidazol-2-thione (which was prepared by the method as described in U.S. Pat. No. 6,051,570) was used in place of the 5-(4-tert-butoxycarbonyl-piperazin-1-yl)-6-chloro-1,3-dihydro-2H-benzimidazol-2-thione as obtained in Production Example 1, to provide the title compound as a colorless powder.

Workup

  1. customwas prepared by the method
  2. customas obtained in Production Example 1

Sources & evidence

ORD record
ord-68aae5d81e514cc78ff711c24a5f04ba
Source dataset
uspto-grants-2005_11
Patent number
US06969712B2

Reaction notes

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