反应详情

温度

140 °C

To 183 mg of 4-cyano-3-fluoro-6-nitroaniline (which was synthesized following J. Med. Chem. 1994, 37, 467) and 201 mg of 1-ethyl-3-pyrrolidinol, 0.5 ml of diisopropylethylamine was added and stirred for 3 hours at 140° C. The reaction liquid was cooled to room temperature, and concentrated after addition of chloroform-methanol (1/1). The residue was separated and purified on preparative thin-layer chromatography [Kieselgel™ 60F254, Art.5744 (Merck); chloroform/methanol=4/1] to provide 114 mg of the title compound as a yellow solid.

1. customThe reaction liquid
2. temperaturewas cooled to room temperature
3. concentrationconcentrated
4. additionafter addition of chloroform-methanol (1/1)
5. customThe residue was separated
6. custompurified on preparative thin-layer chromatography [Kieselgel™ 60F254, Art.5744 (Merck); chloroform/methanol=4/1]