4-Amino-2-fluoro-5-nitrobenzonitrile → HCID 22273128, compound

HRID 1064369Notes

Reaction equation

HRID 1064369 reaction equation
[C:1]([C:3]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:6]([NH2:7])=[CH:5][C:4]=1F)#N.[CH2:14]([N:16]1[CH2:21][CH2:20][NH:19][CH:18]([CH3:22])[CH2:17]1)[CH3:15]>>[CH2:14]([N:16]1[CH2:21][CH2:20][N:19]([C:4]2[C:3]([CH3:1])=[CH:9][C:8]([N+:10]([O-:12])=[O:11])=[C:6]([CH:5]=2)[NH2:7])[CH:18]([CH3:22])[CH2:17]1)[CH3:15]

Participants

3

Reactant 2

HCID 104197934-Amino-2-fluoro-5-nitrobenzonitrileHCID 219119581-Ethyl-3-methylpiperazine

Product 1

HCID 22273128HCID 22273128, compound

Procedure

A reaction was conducted by the method similar to Example 143-1) except that the compound of 1) above was used in place of 4-cyano-3-fluoro-6-nitroaniline and 1-ethyl-3-methylpiperazine was used in place of 1-tert-butoxycarbonyl-3-methylpiperazine, to provide the title compound as an orange-yellow solid.

Sources & evidence

ORD record
ord-d74ab5fa57404803a9f283aea941846e
Source dataset
uspto-grants-2005_11
Patent number
US06969712B2

Reaction notes

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