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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 106438Generated: October 31, 2026

Diethyl Ether → 1-Methyl-4-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)piperazine

https://huagongshe.com/reaction/106438

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDiethyl EtherHCID 3283—
ReactantPiperidineHCID 8082—
ReactantTriethylamineHCID 8471—
ReactantTriphenylphosphineHCID 11776—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
ReactantTrimethylsilylacetyleneHCID 66111—
Reactant5-Bromo-2-(4-methylpiperazin-1-yl)pyridineHCID 16414206—
Product1-Methyl-4-(5-((trimethylsilyl)ethynyl)pyridin-2-yl)piperazineHCID 66730418—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (2/10)
ORD IDord-ad396eb66ebe4327949bdcda64b421dc
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (2/10)