2-Methanesulfonylbenzene-1-sulfonyl chloride → Benzenesulfonamide

HRID 1064468Notes

Reaction equation

HRID 1064468 reaction equation
NC1C=CC(N2CCN(C(OC(C)(C)C)=O)CC2)=CC=1[NH:21][S:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)(=[O:24])=[O:23].CS(C1C=CC=CC=1S(Cl)(=O)=O)(=O)=O>>[C:25]1([S:22]([NH2:21])(=[O:24])=[O:23])[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 27351782-Methanesulfonylbenzene-1-sulfonyl chlorideHCID 22272479N-(2-amino-5-(4-boc-1-piperazinyl)-phenyl)-benzenesulfonamide

Product 1

HCID 7370Benzenesulfonamide

Procedure

2-(Methylsulfonyl)-N-[2-[phenylsulfonyl)amino]-4-(1-piperazinyl)phenyl]benzenesulfonamide was synthesized from N-{2-amino-5-(4-t-butyloxycarbonyl-piperazinyl)-phenyl}benzenesulfonamide and 2-methylsulfonylbenzenesulfonylchloride (61 mg, 0.239 mmol) according to general method 3 to give 70 mg of a purple solid. MS (posES-FIA) m/z=Found: 551.2. Calcd: 551.10. 1H-NMR δ 8.36-7.46 (m, 9H), 6.95 (d, 1H), 6.68 (dd, 1H), 6.46 (d, 1H), 3.47 (s, 3H), 3.28-3.17 (m, 8H).

Sources & evidence

ORD record
ord-cb47781ff380464fb8055f11a4bcb5f1
Source dataset
uspto-grants-2005_11
Patent number
US06969710B2

Reaction notes

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