5-Aminoisoquinoline → HCID 10274446, compound

HRID 1064567Notes

Reaction equation

HRID 1064567 reaction equation
Cl.[CH3:2][C@H:3]1[N:8]([C:9]2[C:10]3[CH:17]=[CH:16][S:15][C:11]=3[N:12]=[CH:13][N:14]=2)[C@@H:7]([CH3:18])[CH2:6][N:5]([CH2:19][C:20]([OH:22])=O)[CH2:4]1.[NH2:23][C:24]1[CH:33]=[CH:32][CH:31]=[C:30]2[C:25]=1[CH:26]=[CH:27][N:28]=[CH:29]2>>[CH3:18][C@H:7]1[N:8]([C:9]2[C:10]3[CH:17]=[CH:16][S:15][C:11]=3[N:12]=[CH:13][N:14]=2)[C@@H:3]([CH3:2])[CH2:4][N:5]([CH2:19][C:20]([NH:23][C:24]2[CH:33]=[CH:32][CH:31]=[C:30]3[C:25]=2[CH:26]=[CH:27][N:28]=[CH:29]3)=[O:22])[CH2:6]1

Participants

3

Reactant 2

HCID 707665-AminoisoquinolineHCID 131725228HCID 131725228, compound

Product 1

HCID 10274446HCID 10274446, compound

Procedure

The title product was prepared from the product of step (ii) (0.2 g) and 5-aminoisoquinoline (0.084 g) by the method of Example 8 step (v) as a white solid. Yield 0.11 g.

Sources & evidence

ORD record
ord-20e301b445544c18ad886c56c482c266
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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