Benzenesulfonyl chloride → HCID 10224011, compound

HRID 1064572Notes

Reaction equation

HRID 1064572 reaction equation
[C:1]1([S:7](Cl)(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[NH:18][C:19](=[O:29])[CH2:20][N:21]1[CH2:26][C@H:25]([CH3:27])[NH:24][C@H:23]([CH3:28])[CH2:22]1>N1C=CC=CC=1>[C:1]1([S:7]([N:24]2[C@@H:25]([CH3:27])[CH2:26][N:21]([CH2:20][C:19]([NH:18][C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][C:12]=3[Cl:11])=[O:29])[CH2:22][C@H:23]2[CH3:28])(=[O:9])=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 7369Benzenesulfonyl chlorideHCID 69746814HCID 69746814, compound

Product 1

HCID 10224011HCID 10224011, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Benzenesulphonyl chloride (0.124 g) was added to a solution of the product from Example 15 step (ii) (0.2 g) in pyridine (2 ml). The mixture was stirred at room temperature for 16 hours and then the solvent was evaporated under reduced pressure. The residue was purified by flash silica-gel chromatography eluting with 1% EtOH, 1% Et3N, 98% CH2Cl2 followed by trituration with ethyl acetate to give the title compound. Yield 0.03 g.

Workup

  1. customthe solvent was evaporated under reduced pressure
  2. customThe residue was purified by flash silica-gel chromatography
  3. washeluting with 1% EtOH, 1% Et3N, 98% CH2Cl2

Sources & evidence

ORD record
ord-ba7eb9c3235c4c729369b91c68b83c7a
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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