3,8-Diazabicyclo[3.2.1]octane-8-carboxylate → 3-[(2-Oxo-2,3-dihydro-1H-indol-4ylcarbamoyl)-methyl]-3,8-diazabicyclo[3.2.1]octan-8-carboxylic acid, 1,1-dimethylethyl Ester

HRID 1064578Notes

Reaction equation

HRID 1064578 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:14]=[CH:13][CH:12]=[C:11]2[C:7]=1[CH2:8][C:9](=[O:15])[NH:10]2)=[O:4].[CH:16]12[N:23]([C:24]([O-:26])=[O:25])[CH:20]([CH2:21][CH2:22]1)[CH2:19][NH:18][CH2:17]2>>[O:15]=[C:9]1[CH2:8][C:7]2[C:11](=[CH:12][CH:13]=[CH:14][C:6]=2[NH:5][C:3]([CH2:2][N:18]2[CH2:19][CH:20]3[N:23]([C:24]([O:26][C:7]([CH3:11])([CH3:8])[CH3:6])=[O:25])[CH:16]([CH2:22][CH2:21]3)[CH2:17]2)=[O:4])[NH:10]1

Participants

3

Reactant 2

HCID 222733503,8-Diazabicyclo[3.2.1]octane-8-carboxylateHCID 222733972-Chloro-N-(2-oxo-2,3-dihydro-1H-indol-4-yl)acetamide

Product 1

HCID 866020003-[(2-Oxo-2,3-dihydro-1H-indol-4ylcarbamoyl)-methyl]-3,8-diazabicyclo[3.2.1]octan-8-carboxylic acid, 1,1-dimethylethyl Ester

Procedure

The subtitle compound was prepared from the product of step (i) (0.24 g) and 1,1-dimethyl, 3,8-diazabicyclo[3.2.1]octane-8-carboxylate (0.26 g) by the method of Example 19 step (i) Yield: 0.8 g

Sources & evidence

ORD record
ord-80a832a66c1e4042bdb68bc0941c8276
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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