Chloroacetyl chloride → 2-chloro-N-(3-fluoro-2-methylphenyl)acetamide

HRID 1064580Notes

Reaction equation

[F:1][C:2]1[C:3]([CH3:9])=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[Cl:10][CH2:11][C:12](Cl)=[O:13]>>[Cl:10][CH2:11][C:12]([NH:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([F:1])[C:3]=1[CH3:9])=[O:13]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 2855533-Fluoro-2-methylaniline

Product 1

HCID 9542492-chloro-N-(3-fluoro-2-methylphenyl)acetamide

Procedure

The subtitle compound was prepared from 3-fluoro-2-methylaniline (0.232 g) and chloroacetyl chloride (0.164 ml) by the method of Example 33 step (iii) as a beige solid. Yield: 0.3 g

Sources & evidence

ORD record: ord-cfab81a6512d4dde857f12972a6643dd
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06969713B2

Reaction notes

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