2-Amino-1-methylbenzimidazole → HCID 60045674, compound

HRID 1064582Notes

Reaction equation

HRID 1064582 reaction equation
Cl.[CH3:2][C@H:3]1[N:8]([C:9]2[C:10]3[CH:17]=[CH:16][S:15][C:11]=3[N:12]=[CH:13][N:14]=2)[C@@H:7]([CH3:18])[CH2:6][N:5]([CH2:19][C:20](O)=[O:21])[CH2:4]1.[NH2:23][C:24]1[N:28]([CH3:29])[C:27]2[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=2[N:25]=1>>[CH3:2][C@H:3]1[N:8]([C:9]2[C:10]3[CH:17]=[CH:16][S:15][C:11]=3[N:12]=[CH:13][N:14]=2)[C@@H:7]([CH3:18])[CH2:6][N:5]([CH2:19][C:20]([NH:23][C:24]2[N:28]([CH3:29])[C:27]3[CH:30]=[CH:31][CH:32]=[CH:33][C:26]=3[N:25]=2)=[O:21])[CH2:4]1

Participants

3

Reactant 2

HCID 741872-Amino-1-methylbenzimidazoleHCID 131725228HCID 131725228, compound

Product 1

HCID 60045674HCID 60045674, compound

Procedure

The title compound was prepared from the product of Example 9 step (ii) (0.2 g) and 2-amino-1-methyl-benzimidazole (0.14 g) by the method of Example 38 step (iv). Purification was by silica gel chromatography followed by recrystallisation from methanol. Yield 45 mg.

Workup

  1. customPurification
  2. customfollowed by recrystallisation from methanol

Sources & evidence

ORD record
ord-3988d7a32e9a4b9fa2e3e1a1976df314
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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