N-methyl-2-pyrrolidone → HCID 60045645, compound

Participants

Reaction Steps

1,1-Dimethylethyl, 4-(4-quinazolinyl)-3,5-dimethylpiperazine-1-carboxylate 4-Chloroquinazoline (6 g), cis-1,1-diethylethyl, 3,5-dimethylpiperazine-1-carboxylate (7.8 g), N,N-diisopropylethylamine (32 ml) in 1-methyl-2-pyrrolidinone (70 ml) were heated at 120° C. for 6 days under nitrogen. The mixture was partitioned between ethyl acetate and brine. The organic phase collected and further washed with brine (×2), collected, dried (MgSO4) and solvent evaporated under reduced pressure to leave a pale brown solid. Purification was by silica gel chromatograpy eluting with ethyl acetate/iso-hexane (3:7) to give the subtitle compound as a pale yellow oil. Yield: 1.1 g

Provenance & Evidence