Sodium Bicarbonate → HCID 69745804, compound

Participants

Reaction Steps

A mixture of 2-chloro-N-(quinolin-5-yl)acetamide (7.76 g) (J. Indian Chem Soc, 1940, 17, 619-621), cis-2,6-dimethylpiperazine (4.42 g), sodium bicarbonate (8.9 g) in ethanol (100 ml) was heated at reflux for 4 h. The solvent was removed under reduced pressure. The residue was partitioned between chloroform and brine. The organic phase collected and the aqeuous phase further extracted (×6) with chloroform. The combined extracts dried (MgSO4) and solvent removed under reduced pressure. Yield: 6.8 g

Provenance & Evidence