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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1064587Generated: October 27, 2026

2-chloro-N-(3-fluoro-2-methylphenyl)acetamide → cis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamide

https://huagongshe.com/reaction/1064587

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-chloro-N-(3-fluoro-2-methylphenyl)acetamideHCID 954249—
Reactantrel-(2R,6S)-2,6-dimethylpiperazineHCID 6950261—
Productcis-(3,5-Dimethylpiperazin-1-yl)-N-(2-methyl-3-fluorophenyl)acetamideHCID 69746587—

Reaction Steps

The subtitle compound was prepared from the product of Example 36 step (i) (14.5 g) and cis-2,6-dimethylpiperazine (9.0 g) by the method of Example 58 step (i) as cream solid. Yield: 11.48 g

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06969713B2
Source datasetuspto-grants-2005_11
ORD IDord-89d9a2d4b206406ea519fdeed7c25a0c
Source noteuspto-grants-2005_11