rel-(2R,6S)-2,6-dimethylpiperazine → HCID 69745130, compound

HRID 1064591Notes

Reaction equation

HRID 1064591 reaction equation
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:7]=1[CH3:14])=[O:4].[CH3:15][C@H:16]1[CH2:21][NH:20][CH2:19][C@@H:18]([CH3:22])[NH:17]1>>[CH3:15][C@H:16]1[NH:17][C@@H:18]([CH3:22])[CH2:19][N:20]([CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:13])[C:7]=2[CH3:14])=[O:4])[CH2:21]1

Participants

3

Reactant 2

HCID 6950261rel-(2R,6S)-2,6-dimethylpiperazineHCID 22273404HCID 22273404, compound

Product 1

HCID 69745130HCID 69745130, compound

Procedure

The subtitle compound was prepared from 2-chloro-N-(3-methoxy-2-methylphenyl)acetamide (10.72 g) and cis-2,6-dimethylpiperazine (6.29 g) by the method of Example 58 step (i) as a tan solid. Yield: 13.13 g

Sources & evidence

ORD record
ord-d7df8dcc43b64f95a0df326ee581e8d5
Source dataset
uspto-grants-2005_11
Patent number
US06969713B2

Reaction notes

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