(R)-3-Pyrrolidinol → HCID 9996868, compound

HRID 1064660Notes

Reaction equation

HRID 1064660 reaction equation
CS(O[CH2:6][CH2:7][C:8]1[O:9][C:10]2[CH:16]=[CH:15][C:14]([C:17]3[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=3)=[CH:13][C:11]=2[CH:12]=1)(=O)=O.[OH:25][C@@H:26]1[CH2:30][CH2:29][NH:28][CH2:27]1>>[OH:25][C@@H:26]1[CH2:30][CH2:29][N:28]([CH2:6][CH2:7][C:8]2[O:9][C:10]3[CH:16]=[CH:15][C:14]([C:17]4[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=4)=[CH:13][C:11]=3[CH:12]=2)[CH2:27]1

Participants

3

Reactant 2

HCID 2759337(R)-3-PyrrolidinolHCID 113936782-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl Methanesulfonate

Product 1

HCID 9996868HCID 9996868, compound

Procedure

The product from Example 1C and 3-(R)-hydroxypyrrolidine were processed as described in Example 1D to provide the titled compound. 1H NMR (300 MHz, CD3OD) δ 7.88 (m, 1H), 7.80 (m, 4H), 7.60 (m, 2H), 6.80 (s, 1H), 4.55 (bs, 1H), 3.8-3.9 (m, 4H), 3.25-3.5 (m, 4H), 2.05-2.4 (m, 2H); MS (DCI) m/z 333 (M+H)+;

Sources & evidence

ORD record
ord-fec26ca7b5f44822925058e1048ca76d
Source dataset
uspto-grants-2005_11
Patent number
US06969730B2

Reaction notes

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