Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Morpholine → 4'-(4-Morpholinylcarbonyl)[1,1'-biphenyl]-4-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Morpholine | HCID 8083 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 4'-Hydroxy-4-biphenylcarboxylic acid | HCID 301556 | — |
| 반응물 | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4'-(4-Morpholinylcarbonyl)[1,1'-biphenyl]-4-ol | HCID 22274689 | 83.2% |
반응 단계
To a solution of 4-hydroxy-biphenyl-4′-carboxylic acid (5.35 g, 25.0 mmol), morpholine (2.39 g, 27.5 mmol) and triethylamine (3.5 mL, 25 mmol) in dichloromethane (100 mL) was added 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride. The mixture was stirred for 16 hours, diluted with aqueous NaH2PO4 and filtered. The solid was washed with 1:2 diethyl ether/water (100 mL) then with water (400 mL). The solid was dried in vacuo to give the titled compound (5.89 g, 83%). MS (DCI) m/z 284 (M+H)+;
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06969730B2 |
| 출처 데이터셋 | uspto-grants-2005_11 |
| ORD ID | ord-8d778ba48f3d4a559fbb6ba14c4a7c77 |
| 출처 메모 | uspto-grants-2005_11 |