Iodine → (3-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanone

HRID 1064718Notes

Reaction equation

HRID 1064718 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1.[I-:17].[K+].II>>[F:1][C:2]1[CH:3]=[C:4]([C:8]([C:10]2[CH:11]=[CH:12][C:13]([OH:16])=[C:14]([I:17])[CH:15]=2)=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 3

HCID 807IodineHCID 4875Potassium IodideHCID 11356363(3-Fluorophenyl)(4-hydroxyphenyl)methanone

Product 1

HCID 11325317(3-Fluorophenyl)(4-hydroxy-3-iodophenyl)methanone

Procedure

The product from Example 69A, potassium iodide and iodine were processed as described in Example 68A to provide the title compound. 1HNMR (300 MHz, CD3OD) δ 6.92 (d, 1H, J=8.9 Hz), 7.31-7.59 (m, 4H), 7.67 (d, 1H, J=8.9 Hz), 8.18 (s, 1H); MS (DCI) m/z 343 (M+H)+, 360 (M+NH4)+.

Sources & evidence

ORD record
ord-5fb993773e824f05a12aae46c42163c1
Source dataset
uspto-grants-2005_11
Patent number
US06969730B2

Reaction notes

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