HCID 11234748, compound → HCID 86586408, compound

Participants

Reaction Steps

The product from Example 145 and cyclopentylmagnesium bromide were processed as described in Example 146, except that additional cyclopentylmagnesium bromide was added after the reaction had stirred overnight (400 mol %) and after another four hours (600 mol %). The reaction mixture was allowed to stir for three additional days (16% yield). MS (ESI APCI) m/z 334 (M+H)+; 1HNMR (300 MHz, CD3OD) δ 1.17 (d, 3 H), 1.38-1.53 (m, 1 H), 1.77-1.86 (m, 2 H), 1.94-2.08 (m, 1 H), 2.23-2.34 (m, 1 H), 2.40-2.59 (m, 2 H), 2.94-3.15 (m, 2 H), 3.19-3.34 (m, 2 H), 6.63 (d, 1 H), 7.51-7.54 (m, 2 H), 7.65 (dd, 1 H), 7.80 (dd, 1 H), 7.87 (ddd, 1 H), 7.96 (ddd, 1 H), 8.16 (dd, 1 H), 10.07 (s, 1 H).

Provenance & Evidence