HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 22274506, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Methanesulfonic Acid | HCID 6395 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 2-[5-(4-cyanophenyl)-1-benzofuran-2-yl]ethyl Methanesulfonate | HCID 11393678 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22274506 | HCID 22274506 | 71% |
Reaction Steps
Methanesulfonic acid (109 mg, 0.32 mmol), the product from Example 1C and sodium azide (83 mg, 1.28 mmol) was stirred in DMF for 4 days, then poured into dichloromethane and washed with water. The crude product was purified by flash chromatography, eluting with 2:1 dichloromethane/hexane to provide the title compound as a clear syrup (65 mg, 71%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969730B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-f480a76a063e4bbdb0dd3f0c7f4d2542 |
| Source note | uspto-grants-2005_11 |