3-Cyanophenylboronic acid → 3-[2-(3-Hydroxypropyl)-1-benzofuran-5-yl]benzonitrile

HRID 1064786Notes

Reaction equation

HRID 1064786 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][CH2:11][CH2:12][OH:13])=[CH:7][C:6]=2[CH:14]=1.[C:15]([C:17]1[CH:18]=[C:19](B(O)O)[CH:20]=[CH:21][CH:22]=1)#[N:16]>>[OH:13][CH2:12][CH2:11][CH2:10][C:8]1[O:9][C:5]2[CH:4]=[CH:3][C:2]([C:21]3[CH:22]=[C:17]([CH:18]=[CH:19][CH:20]=3)[C:15]#[N:16])=[CH:14][C:6]=2[CH:7]=1

Participants

3

Reactant 2

HCID 27343253-Cyanophenylboronic acidHCID 222746933-(5-Bromo-1-benzofuran-2-yl)propan-1-ol

Product 1

HCID 222746073-[2-(3-Hydroxypropyl)-1-benzofuran-5-yl]benzonitrile

Procedure

The product from Example 170A(193 mg, 0.80 mmol) and 3-cyanophenylboronic acid is processed as described in Example 112C to provide the title compound.

Sources & evidence

ORD record
ord-ecf34c07bdd44fe88a6192603d84b78a
Source dataset
uspto-grants-2005_11
Patent number
US06969730B2

Reaction notes

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