Potassium Carbonate → HCID 22272818, compound

Participants

Reaction Steps

To a solution of 1-(3-hydroxypropyl)piperazine (700 mg, 4.88 mmol) in acetonitrile (15 ml) were added potassium carbonate (805 mg, 5.82 mmol) and 2-bromo-N-(2,6-diisopropyl-4-hydroxyphenyl)acetamide (1.53 g, 4.88 mmol), and the mixture was stirred at room temperature for 1 hour. To the reaction solution was added a saturated ammonium chloride solution and the mixture was extracted with chloroform-methanol mixture solvent. The organic layer was washed with water and a saturated sodium chloride successively and dried over anhydrous sodium sulfate, and the solvent was evaporated therefrom. The resulting residue was recrystallized from chloroform-methanol-hexane to provide 1.13 g (yield 62%) of 2-[4-(3-hydroxypropyl)piperazin-1-yl]-N-[2,6-diisopropyl-4-hydroxyphenyl]acetamide as colorless powdery crystals.

Provenance & Evidence