2-Bromoethyl ethyl ether → HCID 22272766, compound

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Reaction Steps

To a solution of this acetamide (500 mg, 1.32 mmol) solution in DMF (12 ml) were added 2-bromoethyl ethyl ether (7 ml) and potassium fluoride 40 wt. % on alumina (40 wt. %, 1.96 g, 13.2 mmol), and the mixture was stirred at room temperature for 5 days. After the catalyst was filtered off, the filtrate was diluted with water and extracted with ethylacetate. The organic layer was washed with a saturated sodium chloride solution and dried over anhydrous sodium sulfate, and the solvent was evaporated therefrom. The resulting residue was purified by a silica gel column chromatography (developing solvent; chloroform:methanol=30:1) to provide 448 mg (yield 78%) of N-[2,6-diisopropyl-4-(2-ethoxyethyloxy)phenyl]-2-[4-(3-hydroxypropyl)piperazin-1-yl]acetamide as colorless powdery crystals.

Provenance & Evidence