Nitric Acid → HCID 178433493, compound

HRID 1064858Notes

Reaction equation

HRID 1064858 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([OH:8])[N:5]=[C:4]([CH3:9])[N:3]=1.[N+:10]([O-])([OH:12])=[O:11]>>[OH:1][C:2]1[C:7]([N+:10]([O-:12])=[O:11])=[C:6]([OH:8])[N:5]=[C:4]([CH3:9])[N:3]=1

Participants

3

Reactant 2

HCID 944Nitric AcidHCID 178418389HCID 178418389, compound

Product 1

HCID 178433493HCID 178433493, compoundYield 15%

Procedure

4,6-Dihydroxy-2-methylpyrimidine (1.00 g, 7.93 mmol) was added gradually to fuming nitric acid (3 ml) with ice-cooling, and the mixture was stirred at that temperature for 2 hours and then at room temperature for 1 hour. The reaction solution was poured into ice, and the precipitated crystal was filtered off and dried to provide 207 mg (yield 15%) of 4,6-dihydroxy-2-methyl-5-nitropyrimidine.

Workup

  1. temperaturecooling
  2. waitat room temperature for 1 hour
  3. additionThe reaction solution was poured into ice
  4. filtrationthe precipitated crystal was filtered off
  5. customdried

Sources & evidence

ORD record
ord-6057872a764348e798f613cef5512fe6
Source dataset
uspto-grants-2005_11
Patent number
US06969711B2

Reaction notes

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