反应详情

4,6-Dihydroxy-2-methylpyrimidine (1.00 g, 7.93 mmol) was added gradually to fuming nitric acid (3 ml) with ice-cooling, and the mixture was stirred at that temperature for 2 hours and then at room temperature for 1 hour. The reaction solution was poured into ice, and the precipitated crystal was filtered off and dried to provide 207 mg (yield 15%) of 4,6-dihydroxy-2-methyl-5-nitropyrimidine.

1. temperaturecooling
2. waitat room temperature for 1 hour
3. additionThe reaction solution was poured into ice
4. filtrationthe precipitated crystal was filtered off
5. customdried