Sodium borohydride → HCID 22272611, compound

Participants

Reaction Steps

To a mixed solution of this aldehyde (745 mg, 3.63 mmol) in dichloromethane (5 ml) and methanol (10 ml) was added sodium borohydride (280 mg, 7.40 mmol) with ice-cooling and stirred at room temperature for 1 hour. The reaction solution was diluted with water and extracted with chloroform. The organic layer was washed with a saturated sodium hydrochloride solution, dried over anhydrous sodium sulfate and concentrated in vacuo. The resulting residue was purified by a silica gel column chromatography (silica gel 50 g, developing solvent; hexane:ethyl acetate=6:1 2:1) to provide 736 mg (yield 98%) of 4-amino-3,5-diisopropylbenzenemethanol as colorless oil.

Provenance & Evidence