反应详情

To a solution of 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (4.58 g, 9.11 mmol) obtained in Example 32 in ethanol (170 ml) was added maleic acid (2.11 g, 18.2 mmol) with ice-cooling. The mixture was homogenized by adding chloroform (20 ml) and concentrated in vacuo. The resulting reside was crystallized from ethanol-ether to provide 5.27 g (yield 77%) of 2-[4-[2-(benzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide dimaleate.

1. temperaturecooling
2. concentrationconcentrated in vacuo
3. customThe resulting reside was crystallized from ethanol-ether