Triethylamine → HCID 178527819, compound

Participants

Reaction Steps

To a solution of 2,3-diaminopyridine (286 mg, 2.62 mmol) in THF (10 ml) were added thiophosgene (300 mg, 2.62 mmol) and triethylamine (265 mg, 2.62 mmol), and the mixture was stirred at room temperature for 20 hours. The reaction mixture was concentrated in vacuo, and the resulting residue was purified by a silica gel preparative thin layer chromatography (developing solvent; chloroform:sat. ammonia methanol=10:1) to provide 39 mg (yield 10%) of 2-mercaptoimidazolo[4,5-b]pyridine.

Provenance & Evidence