Trifluoroacetic acid → HCID 22272828, compound

Participants

Reaction Steps

2-[4-[2-(5-benzyloxybenzimidazol-2-ylthio)ethyl]piperazin-1-yl]-N-[2,4-bis(methylthio)-6-methyl-3-pyridyl]acetamide (115 mg, 0.189 mmol) obtained in Example 150 was dissolved into trifluoroacetic acid (2 ml) and stirred at room temperature for 23 hours. The reaction solution was concentrated in vacuo, and the resulting residue was purified by a silica gel preparative thin layer chromatography (developing solvent; chloroform:sat. ammonia methanol=10:1) to provide 75 mg (yield 76%) of the desired compound as colorless powdery crystals. IR (KBr) cm−1: 3227, 1675, 1600, 1564, 1486. 1H-NMR (CDCl3) δ: 2.36 (3H, s), 2.45 (3H, s), 2.47 (3H, s), 2.50-3.00 (10H, m), 3.10 (2H, s), 3.14 (2H, br s), 6.61 (1H, s), 6.74 (1H, d, J=8.8 Hz), 7.00 (1H, s), 7.29 (1H, d, J=8.8 Hz), 8.41 (1H, s).

Provenance & Evidence