Sodium Hydroxide → (Z)-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid

HRID 1064893Notes

Reaction equation

HRID 1064893 reaction equation
C([O:3][C:4](=[O:31])/[C:5](/[O:28][CH2:29][CH3:30])=[CH:6]/[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:19]=2[CH3:20])=[CH:9][C:8]=1[CH3:27])C.[OH-].[Na+]>>[CH2:29]([O:28]/[C:5](=[CH:6]\[C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[N:16]=[C:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)[O:18][C:19]=2[CH3:20])=[CH:9][C:8]=1[CH3:27])/[C:4]([OH:31])=[O:3])[CH3:30]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 69280705(Z)-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid ethyl ester

Product 1

HCID 22273940(Z)-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid

Procedure

In analogy to the procedure described in example 1a f], (Z)-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid ethyl ester was treated with NaOH to obtain (Z)-2-ethoxy-3-[2-methyl-4-(5-methyl-2-phenyl-oxazol-4-ylmethoxy)-phenyl]-acrylic acid as colorless solid.

Sources & evidence

ORD record
ord-fe55893d906a433786ebf3ba9ffba0cf
Source dataset
uspto-grants-2005_11
Patent number
US06969725B2

Reaction notes

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