化工社化工社 化学情報印刷レポート · 研究参考用
Potassium Iodide → (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Cesium carbonate | HCID 10796 | — |
| 反応物 | Phosphorus oxychloride | HCID 24813 | — |
| 反応物 | 3,5-Dimethoxybenzaldehyde | HCID 81747 | — |
| 反応物 | Oxazole, 4-(chloromethyl)-2-(3,5-dimethoxyphenyl)-5-methyl- | HCID 21974252 | — |
| 反応物 | (S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester | HCID 68616579 | — |
| 生成物 | (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid methyl ester | HCID 69280726 | — |
反応手順
In analogy to the procedure described in example 1 f], (2S)-2-ethoxy-3-(4-hydroxy-2-methyl-phenyl)-propionic acid methyl ester (example 1 d]) was reacted with 4-chloromethyl-2-(3,5-dimethoxy-phenyl)-5-methyl-oxazole (prepared from 3,5-dimethoxy-benzaldehyde and diacetyl monoxyme followed by treatment with POCl3 in analogy to the procedures described in examples 2 a] and b]) in the presence of cesium carbonate and potassium iodide to yield (S)-3-{4-[2-(3,5-dimethoxy-phenyl)-5-methyl-oxazol-4-ylmethoxy]-2-methyl-phenyl}-2-ethoxy-propionic acid methyl ester as colorless liquid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06969725B2 |
| 出典データセット | uspto-grants-2005_11 |
| ORD ID | ord-db21a1130dc54fd1ae0402df97e38b86 |
| 出典メモ | uspto-grants-2005_11 |