Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1064928Generated: October 31, 2026

Triethylsilane → (2S)-3-(4-benzyloxy-2-fluoro-phenyl)-2-ethoxy-propionic acid methyl ester

https://huagongshe.com/reaction/1064928

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylsilaneHCID 12052—
ReactantHCID 68617112HCID 68617112—
SolventTrifluoroacetic acidHCID 6422—
Product(2S)-3-(4-benzyloxy-2-fluoro-phenyl)-2-ethoxy-propionic acid methyl esterHCID 68616088—

Reaction Steps

In analogy to the procedure described in example 1 c], (2S,3R)-3-(4-benzyloxy-2-fluoro-phenyl)-2-ethoxy-3-hydroxy-propionic acid methyl ester was treated with triethylsilane in trifluoroacetic acid to yield (2S)-3-(4-benzyloxy-2-fluoro-phenyl)-2-ethoxy-propionic acid methyl ester as colorless liquid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06969725B2
Source datasetuspto-grants-2005_11
ORD IDord-a7110350d0684927be41340b871d5689
Source noteuspto-grants-2005_11