HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-Benzyloxy-2-(trifluoromethyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-(Benzyloxy)-1-bromo-2-(trifluoromethyl)benzene | HCID 22273864 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-Benzyloxy-2-(trifluoromethyl)benzaldehyde | HCID 22273885 | — |
Reaction Steps
In analogy to the procedure described in example 8 c], 1-bromo-2-trifluoromethyl-4-(phenylmethoxy)-benzene was treated with n-BuLi and N,N-dimethylformamide in dry tetrahydrofuran to yield 4-benzyloxy-2-trifluoromethyl-benzaldehyde as colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06969725B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-bc3bf74a827e44eba5c73ae78aa96eb5 |
| Source note | uspto-grants-2005_11 |