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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1064951Generated: October 25, 2026

Triethylsilane → (2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl ester

https://huagongshe.com/reaction/1064951

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylsilaneHCID 12052—
Reactant(2S,3R)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-3-hydroxy-propionic acid methyl esterHCID 69280418—
SolventTrifluoroacetic acidHCID 6422—
Product(2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl esterHCID 69282329—

Reaction Steps

In analogy to the procedure described in example 1 c], (2S,3R)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-3-hydroxy-propionic acid methyl ester was treated with triethylsilane in trifluoroacetic acid to yield (2S)-3-(4-benzyloxy-2-trifluoromethyl-phenyl)-2-ethoxy-propionic acid methyl ester as colorless liquid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06969725B2
Source datasetuspto-grants-2005_11
ORD IDord-1fc637094e9442dfa8fdc6f6d59263df
Source noteuspto-grants-2005_11