Pyridine → HCID 54291171, compound

Participants

Reaction Steps

8.5 g (0.04 mol) of N-(pyrimidin-2-yl-methyl)-2,6-dimethylaniline and 3.2 g (0.04 mol) of pyridine were heated under reflux in 20 ml of tetrahydrofuran. 4.5 g (0.04 mol) of chloroacetyl chloride were added dropwise to this mixture. The reaction mixture was stirred under reflux for 5 hours and then poured onto 300 g of ice. The crystalline precipitate formed was filtered off, washed with water and recrystallized from carbon tetrachloride. 8.2 g (71% of theory) of 2,6-dimethyl-N-(pyrimidin-2-yl-methyl)-chloroacetanilide were obtained in the form of colorless crystals of melting point 110° C.

Provenance & Evidence