HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → 4-[2-(4-Methylphenyl)ethoxy]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-Methyl-4-[2-(4-nitrophenoxy)ethyl]benzene | HCID 5142926 | — |
| Reactant | Sulfur | HCID 5362487 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-[2-(4-Methylphenyl)ethoxy]aniline | HCID 13017656 | 96.9% |
Reaction Steps
4-[2-(4-Methylphenyl)ethoxy]nitrobenzene (VI) (5.14 g, 0.02 mole), sodium hydroxide powder (3.0 g) and sulfur (1.6 g, 0.05 mole) were added to a mixture of acetone (20 ml) and methanol (20 ml), followed by heating under reflux for 5 hours. After cooling, the reaction mixture was diluted with water, extracted with ether and treated in the same manner as in Example 18 to obtain 4.4 g of 4-[2-(4-methylphenyl)ethoxy]aniline (V) (yield, 96.9%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04328166 |
| Source dataset | uspto-grants-1982_05 |
| ORD ID | ord-bf58e061715b4681a929a2fc19b2547d |
| Source note | uspto-grants-1982_05 |