Ethanol → HCID 13017653, compound

HRID 1065055Notes

Reaction equation

HRID 1065055 reaction equation
C[C:2]1([NH:18][C:19](=[O:21])[CH3:20])[CH:17]=[CH:16][C:5]([O:6][CH2:7][C:8]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:9])=[CH:4][CH2:3]1.[H][H].[CH2:24](O)C>[C].[Pd]>[C:19]([NH:18][C:2]1[CH:3]=[CH:4][C:5]([O:6][CH2:7][CH:8]([OH:9])[C:10]2[CH:11]=[CH:12][C:13]([CH3:24])=[CH:14][CH:15]=2)=[CH:16][CH:17]=1)(=[O:21])[CH3:20]

Participants

5

Reactant 3

HCID 702EthanolHCID 86737702HCID 86737702, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 13017653HCID 13017653, compound

Reagents, catalysts & solvents 1

HCID 178418390HCID 178418390, compoundCatalyst

Procedure

10% Palladium-carbon (0.1 g) was added to a solution of 4-methyl-α-(4-acetamidophenoxy)acetophenone (XIII: R=CH3) (2.83 g, 0.01 mole) in ethanol (50 ml), and catalytic reduction was carried out at 25° C. for 2 hours during which 290 ml of hydrogen was absorbed. After removing the catalyst by filtration, after-treatment was carried out in the same manner as in Example 35 to obtain 2.55 g of β-(4-acetamidophenoxy)-α-(4-methylphenyl)ethyl alcohol (XIV: R=CH3) as white crystals (yield, 89.5%).

Workup

  1. customwas absorbed
  2. customAfter removing the catalyst
  3. filtrationby filtration
  4. customto obtain

Sources & evidence

ORD record
ord-b8241f1643344112b7eacde84f880bcf
Source dataset
uspto-grants-1982_05
Patent number
US04328166

Reaction notes

Loading…