Sodium Hydroxide → 5-Carbamoyl-3-hydroxymethyl-2,4,6-triiodobenzoic acid

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Reaction Steps

27.8 g of 5-cyano-3-hydroxymethyl-2,4,6-triiodobenzoic acid is suspended in 120 ml of water and dissolved by adding 10 g of sodium hydroxide. The batch is held at 60° C. for 3 hours and then precipitated into 50 ml of semiconcentrated sulfuric acid. After several hours of agitation in an ice bath, the precipitate is vacuum-filtered, washed with water, and dried at 50° C., thus obtaining 25 g of 5-carbamoyl-3-hydroxymethyl-2,4,6-triiodobenzoic acid as a white powder with a decomposition point above 280° C. Yield: 88% of theory.

Provenance & Evidence