Ammonia → HCID 20541184, compound

HRID 1065068Notes

Reaction equation

HRID 1065068 reaction equation
Cl[C:2]1[NH:3][C:4]2[CH:5]=[CH:6][CH:7]=[C:8]3[C:14]=2[CH:12]([N:13]=1)[CH2:11][CH2:10][CH2:9]3.[NH3:15]>C(O)C>[NH2:15][C:2]1[NH:3][C:4]2[CH:5]=[CH:6][CH:7]=[C:8]3[C:14]=2[CH:12]([N:13]=1)[CH2:11][CH2:10][CH2:9]3

Participants

4

Reactant 2

HCID 222AmmoniaHCID 20541259HCID 20541259, compound

Product 1

HCID 20541184HCID 20541184, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

62 g (0.3 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine in 400 ml of ethanol and 150 ml of liquid ammonia are heated to 150° in an autoclave for 6 hours. The pressure thereby increases to a maximum of 30 bars. After cooling, the reaction mixture is evaporated to dryness. The residue is dissolved in water, the solution is filtered through active charcoal and the 2-amino-3a,4,5,6-tetrahydroperimidine formed is precipitated by adding aqueous ammonia. After filtering off and drying the product, 40 g (71% of theory) of melting point 230°-232° are obtained. Preparation of 2-chloro-3a,4,5,6-tetrahydro-perimidine:

Workup

  1. temperatureThe pressure thereby increases to a maximum of 30 bars
  2. temperatureAfter cooling
  3. customthe reaction mixture is evaporated to dryness
  4. dissolutionThe residue is dissolved in water
  5. filtrationthe solution is filtered through active charcoal

Sources & evidence

ORD record
ord-755708b8ea794d769408b75d4d0dd2b2
Source dataset
uspto-grants-1982_05
Patent number
US04328223

Reaction notes

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