反应详情

62 g (0.3 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine in 400 ml of ethanol and 150 ml of liquid ammonia are heated to 150° in an autoclave for 6 hours. The pressure thereby increases to a maximum of 30 bars. After cooling, the reaction mixture is evaporated to dryness. The residue is dissolved in water, the solution is filtered through active charcoal and the 2-amino-3a,4,5,6-tetrahydroperimidine formed is precipitated by adding aqueous ammonia. After filtering off and drying the product, 40 g (71% of theory) of melting point 230°-232° are obtained. Preparation of 2-chloro-3a,4,5,6-tetrahydro-perimidine:

1. temperatureThe pressure thereby increases to a maximum of 30 bars
2. temperatureAfter cooling
3. customthe reaction mixture is evaporated to dryness
4. dissolutionThe residue is dissolved in water
5. filtrationthe solution is filtered through active charcoal