反应详情

10.3 g (0.05 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine and 7.1 g (0.05 mol) of 4-chloro-benzylamine in 100 ml of ethanol are heated to 80° C. for 1 hour. After cooling, the crystals which have precipitated are filtered off and purified by dissolving in hot ethanol and precipitating with water. 2-(4-Chlorobenzylamino)-3a,4,5,6-tetrahydro-perimidine hydrochloride is obtained. Yield: 10 g (57.5% of theory) of melting point 257°-258° C.

1. temperatureAfter cooling
2. customthe crystals which have precipitated
3. filtrationare filtered off
4. custompurified
5. dissolutionby dissolving in hot ethanol
6. customprecipitating with water