4-Chlorobenzylamine → HCID 178478544, compound

HRID 1065069Notes

Reaction equation

HRID 1065069 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[CH:5]=[CH:6][CH:7]=[C:8]3[C:14]=2[CH:12]([N:13]=1)[CH2:11][CH2:10][CH2:9]3.[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH2:21])=[CH:18][CH:17]=1>C(O)C>[ClH:1].[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH2:20][NH:21][C:2]2[NH:3][C:4]3[CH:5]=[CH:6][CH:7]=[C:8]4[C:14]=3[CH:12]([N:13]=2)[CH2:11][CH2:10][CH2:9]4)=[CH:18][CH:17]=1

Participants

4

Reactant 2

HCID 660364-ChlorobenzylamineHCID 20541259HCID 20541259, compound

Product 1

HCID 178478544HCID 178478544, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

10.3 g (0.05 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine and 7.1 g (0.05 mol) of 4-chloro-benzylamine in 100 ml of ethanol are heated to 80° C. for 1 hour. After cooling, the crystals which have precipitated are filtered off and purified by dissolving in hot ethanol and precipitating with water. 2-(4-Chlorobenzylamino)-3a,4,5,6-tetrahydro-perimidine hydrochloride is obtained. Yield: 10 g (57.5% of theory) of melting point 257°-258° C.

Workup

  1. temperatureAfter cooling
  2. customthe crystals which have precipitated
  3. filtrationare filtered off
  4. custompurified
  5. dissolutionby dissolving in hot ethanol
  6. customprecipitating with water

Sources & evidence

ORD record
ord-b065bed69cff4c3c87332959814173dc
Source dataset
uspto-grants-1982_05
Patent number
US04328223

Reaction notes

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