反应详情

10.3 g (0.05 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine and 8.6 g (0.055 mol) of N-methyl-N'-aminopropylpiperazine in 50 ml of acetone are heated to 55° C. for 2 hours. After cooling, 50 ml of ether are added and the reaction mixture is placed in a refrigerator for 24 hours. The crystals which have precipitated are filtered off and rinsed with ether. 10.6 g (55.6% of theory) of 2-(4-methylpiperazinopropylamino)-3a,4,5,6-tetrahydro-perimidine hydrochloride hydrate are thereby obtained. Melting point 155°-157° C.

1. temperatureAfter cooling
2. customThe crystals which have precipitated
3. filtrationare filtered off
4. washrinsed with ether