Diethyl Ether → HCID 178480874, compound

HRID 1065070Notes

Reaction equation

HRID 1065070 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[CH:5]=[CH:6][CH:7]=[C:8]3[C:14]=2[CH:12]([N:13]=1)[CH2:11][CH2:10][CH2:9]3.[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][NH2:25])[CH2:18][CH2:17]1.CC[O:28]CC>CC(C)=O>[OH2:28].[ClH:1].[CH3:15][N:16]1[CH2:21][CH2:20][N:19]([CH2:22][CH2:23][CH2:24][NH:25][C:2]2[NH:3][C:4]3[CH:5]=[CH:6][CH:7]=[C:8]4[C:14]=3[CH:12]([N:13]=2)[CH2:11][CH2:10][CH2:9]4)[CH2:18][CH2:17]1

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 783281-(3-Aminopropyl)-4-methylpiperazineHCID 20541259HCID 20541259, compound

Product 1

HCID 178480874HCID 178480874, compoundYield 55.6%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

10.3 g (0.05 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine and 8.6 g (0.055 mol) of N-methyl-N'-aminopropylpiperazine in 50 ml of acetone are heated to 55° C. for 2 hours. After cooling, 50 ml of ether are added and the reaction mixture is placed in a refrigerator for 24 hours. The crystals which have precipitated are filtered off and rinsed with ether. 10.6 g (55.6% of theory) of 2-(4-methylpiperazinopropylamino)-3a,4,5,6-tetrahydro-perimidine hydrochloride hydrate are thereby obtained. Melting point 155°-157° C.

Workup

  1. temperatureAfter cooling
  2. customThe crystals which have precipitated
  3. filtrationare filtered off
  4. washrinsed with ether

Sources & evidence

ORD record
ord-87ca42bd403e44ed974192870ac8cf71
Source dataset
uspto-grants-1982_05
Patent number
US04328223

Reaction notes

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