反应详情

10.3 g (0.05 mol) of 2-chloro-3a,4,5,6-tetrahydroperimidine are introduced into 15 ml of aniline, whilst stirring. After the strongly exothermic reaction has subsided (temperature rises to 90° C.), water is added to the mixture and the crystals which have precipitated are isolated by filtration and washed several times with dilute aqueous ammonia solution. 2-Phenylamino-3a,4,5,6-tetrahydro-perimidine is obtained. Yield: 9.5 g (72% of theory) of melting point 233°-235° C.

1. customAfter the strongly exothermic reaction
2. additionis added to the mixture
3. customthe crystals which have precipitated
4. customare isolated by filtration
5. washwashed several times with dilute aqueous ammonia solution