Acetyl chloride → HCID 12850687, compound

Participants

Reaction Steps

4 g of acetyl chloride were added dropwise to a suspension of 11.4 g of 8-chloro-1,3,4,6-tetrahydro-6-methyl-2H-5,1-benzothiazocine and 10 g of potassium carbonate in 100 ml of acetone, whilst keeping the temperature of the mixture below 10° C. The mixture was stirred for 30 minutes, after which it was poured into ice-water and extracted with chloroform. The solvent was evaporated from the extract and the residue was recrystallized from a 3:2 by volume mixture of methylene chloride and n-hexane to give 5 g of 1-acetyl-8-chloro-1,3,4,6-tetrahydro-6-methyl-2H-5,1-benzothiazocine in the form of crystals melting at 132°-135° C.

Provenance & Evidence