4-Acetylbenzoic Acid → HCID 21041614, compound

HRID 10651Notes

Reaction equation

HRID 10651 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[C:4]=1[CH:5]=O.[C:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)(=[O:20])[CH3:19]>>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([O:11][CH3:12])[CH:8]=[C:7]([C:13]2[S:14][CH:15]=[CH:16][CH:17]=2)[C:4]=1/[CH:5]=[CH:19]/[C:18]([C:21]1[CH:29]=[CH:28][C:24]([C:25]([OH:27])=[O:26])=[CH:23][CH:22]=1)=[O:20]

Participants

3

Reactant 2

HCID 114704-Acetylbenzoic AcidHCID 219810682,4-Dimethoxy-6-thiophen-2-yl-benzaldehyde

Product 1

HCID 21041614HCID 21041614, compoundYield 61%

Procedure

The title compound was prepared by condensing 2,4-dimethoxy-6-thiophen-2-yl-benzaldehyde (Ex-39A) and 4-acetylbenzoic acid in a similar manner as described in Ex-3. Yellow solid, 61% yield, mp 231° C. (dec.). 1H-NMR (DMSO-d6) δ 8.02 (d, 2H), 7.93 (d, 2H), 7.73 (m, 3H), 7.15 (t, 1H), 7.07 (d, 1H), 6.72 (d, 1H), 6.62 (d, 1H). MS m/z=394 ([M]+, 6%), 245 (100%). HRMS m/z: calc. 395.0953, found 395.0949.

Sources & evidence

ORD record
ord-d29e144585dc4ce4b0a63e3261237b63
Source dataset
uspto-grants-2006_08
Patent number
US07094801B2

Reaction notes

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