Ethyl Acetoacetate → HCID 178472877, compound

Participants

Reaction Steps

To a cold (5°) stirred mixture of 3.9 kg. of ethyl acetoacetate in 2.25 liters of glacial acetic acid was added a solution of 2.25 kg. of sodium nitrite in 3 liters of water over one hour at 0°-15°. The reaction mixture was stirred at 0°-15° for six hours and worked up to give ethyl 2-hydroxyimino-acetoacetate (4.57 kg.) in 96% yield.

Provenance & Evidence