反应详情

Trichloroisothiazole (37.7 g, 0.20 mol) and dimethyl sulfate (9.5 ml, 0.1 mol) were mixed under a nitrogen atmosphere. The mixture was heated at 135°-140° for 1 hr. The reaction mixture was cooled and poured into 100 ml of ether. The resulting solid was collected and washed with warm glyme to yield 14.5 g, (46%), mp 130°. The NMR and IR were consistent with the assigned structure.

1. temperatureThe mixture was heated at 135°-140° for 1 hr
2. temperatureThe reaction mixture was cooled
3. customThe resulting solid was collected
4. washwashed with warm glyme
5. customto yield 14.5 g, (46%), mp 130°